Hey, there, this is Erin Ryan from the Dr Ruscio team answering a few of the top questions about our Elemental Heal. I think thats, thats so important. Well just supplement. It recharges our internal antioxidant defense system with glutathione and catalyses and superoxide dismutase so that mitochondrial protection system and detoxification system can work properly the following day. Yes, it is. Why is Mitochondrial Health Important? - spermidineLIFE by Longevity Ari Whittenauthor of Eat for Energy: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy provides nutrition and lifestyle strategies that can be a gamechanger for improving your mitochondrial function and enhancing your energy, focus, mood, and memory. So he had to give up coffee, which he enjoyed. If you tested their cortisol, if they saw a practitioner who believes in adrenal fatigue, they would walk out of that diagnosed with adrenal fatigue. 7 Ways to Support Your Mitochondria - YouTube Physical Exercise: A Novel Tool to Protect Mitochondrial Health Now actually just to make the point, loop it back in with testing, I would actually argue that if that type of testing was easy to do, if it didnt involve sticking a big hollow needle in your thigh and taking a chunk of muscle tissue out, which is pretty painful and most people dont want to do that, that test would actually be extraordinarily insightful because how many mitochondria you have in your cells, your total mitochondrial capacity is enormously important to determining your cellular energy producing capacity. And this is just to take one example. Circadian rhythm disruptions effect on cortisol levels 25:36 Think of the last time you got a cold or a flu or COVID, what was one of the key symptoms of that? Yeah, me too. I mean, treating these things as far upstream as we can. And I think were all on the same page in that regard, but unfortunately there does seem to be this drift in the field toward reductionistic [application of] natural medicines in a model that seems to be more conventional medicine in its framework. Not that I think we should be advocating for the testing, because I dont think the testing is really telling you the cause. Or do you see that as an indicator of some other item being out of whack? Also, I mentioned before that I did about a year-long full-time obsession deep dive into the literature on fatigue syndromes, as it relates to adrenal function, HPA axis function, and cortisol. And its supposed to be sort of the best of modern medicine, what they have to treat chronic fatigue. If you have a mitochondrial disease, your cells aren't able to produce enough energy. Mitochondria supply your cells with vital energy. And this general principle is widespread in nature. Exactly. This function is . Its a phospho lipid supplement. Every product is science-based, validated by real-world use, and personally vetted by Dr. Ruscio, DC. Eat fewer calories. Its not because of peoples unique bioindividuality that all of a sudden is causing rates of these diseases to go up by 300, 500, 1000% percent in the span of a few decades. With a lot of tasks to perform, it's . A healthy person at rest produces their body weight in adenosine triphosphate every day! If someones habituated caffeine use and you take them off that, its almost like saying, Hey, Joe, we have you on testosterone replacement therapy, but were going to check your levels, go off your testosterone before the test. I mean, what do you think youre going to find? This is what I was explaining before. And thats where we have to be, I think a little bit careful. Ari Whittenauthor of Eat for Energy: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energyprovides nutrition and lifestyle strategies that can be a gamechanger for improving your mitochondrial function and enhancing your energy . Because the standard American diet has given rise to a widespread sugar addiction, most people tend to burn glucose. Exactly. And it was their treatment guidelines for mitochondrial dysfunction. Thats fantastic. Do you see this as evidence of a mitochondrial problem? Okay. Im 38 now. They are more the exception than the rule. The solution to the rise of that epidemic and all those tigers in the zoo is not to do individualized testing and figure out what each one of them, their unique biochemistry is, and then tailor custom solutions for each one of their unique biochemistry based on all the testing. And SIBO testing is a great example of this, the hydrogen breath testing, which I know youve talked about as compared to like glucose breath testing or using multiple of the different breath tests. Yeah. Eating well, same thing. And those studies have consistently shown 30, 40% improvements in energy levels in as little as three weeks. So it turns out mitochondria are also environmental sensors. General Health The Care and Feeding of Your Mitochondria They're essential to energy, focus, vitality, and metabolism. Through the clinic we also offer health coaching. That is incredibly insightful to know, and I hope this is resonating with our listeners as much as it is for myself in that we want to stop looking at adrenals and thyroid as this ubiquitous cause of problems with energy. And this specific patented extract of phospho lipids (and phospho lipids for people that dont know also make up our cellular and mitochondrial membranes, things like Phosphatidyl Choline and Phosphatidylethanolamine and several others) and this patented form of phospho lipids has actually been tested in numerous studies in people with various kinds of chronic fatigue. Mitochondria use MitoQ to reline the mitochondrial membrane, helping maintain its structural integrity and the . Cause I can fast a day and Ill feel great, but if I dont eat anything and then I try to go to sleep, I just, I wont sleep well. But they also say, this is more directly related to what youre saying about thyroid and adrenals, they also talk about testing in people with chronic fatigue and they say, this is actually in the paper, they say that only in 5% of cases does anything show up on the lab tests that is an explanatory factor in their fatigue. Meaning 95% of the time, 95 out of every 100 people that come in with chronic fatigue have nothing detectable on their lab test that shows up that can explain their chronic fatigue. You can learn a lot more about our elemental heal formulas at drruscio.com/EH. And its 2022 with the best of modern medicine and all this sophisticated technology and all this fancy research, of course, theyre going to be able to do a blood test on me and figure out whats causing my fatigue. And 95% of the time they tell they can tell you nothing about whats causing your fatigue. So you literally have much less mitochondria. Skin health Jan 20, 2023 Skin health, aging and the cellular powerhouse Inside every cell is a powerhouse called the mitochondria. It so beautifully maps on to everything that Ive tried to bring to peoples awareness regarding gut health and how you can have inflammation in the gut. Body composition, how much fat and muscle you have ties directly into your mitochondrial function through things like, for example, insulin resistance and oxidative stress and levels of inflammatory cytokines. Well, you can order our whey-free version of our Elemental Heal. If youre not a do-it-yourselfer there is always the clinic and myself or any one of our doctors would be more than happy to help you. So tell us about the new book. Theres other limitations though, that are important. So if someone comes to me and lets say I diagnose them with adrenal fatigue and then so theyre sitting there thinking, okay, Ive got adrenal fatigue. 5 Ways to Protect Your Mitochondrial Health | Nutri Advanced The breakthrough formula is absorbed through the mitochondrial membrane and into the mitochondria, hundreds of times more effectively than regular CoQ10 supplements.1. And what Im trying to do is help people understand the connection of these nutrition and lifestyle habits and environmental things with our energy, with the mitochondria, to understand the mechanisms of how they connect. You can order from there as well. Food intolerance testing is notorious for being inaccurate. 100%. Yes, 100%. So let me delve into this a bit because basically the way I conceptualize energy theres two fundamental causes: one is whats going on in the environment and lifestyle level (terms of psychological stress, environmental toxicants, gut health, body composition, circadian rhythm, sleep, nutrition, all these types of things), the other thing is what is actually the status of your mitochondria in your cells? The problem with fasting 01:08:37 So I have no opposition to that at all. Hear how it can help you. Without mitochondria, we would end up with significantly less ATP. We also know that what we eat and how and our body composition ties into our blood sugar regulation. "The chief reason for mitochondrial burnout is the consumption of processed, empty-calorie foods." And they are constantly taking samples of the environment, basically of whats going on in the body, basically asking the question, are we under attack? Well talk to you soon. Ill also mention, just to add to that a bit, that there are some people who might be listening to this thinking, well, I got my cortisol tested and I really do have low cortisol levels. Okay. Thats absolutely fantastic. Right. Today I spoke with Ari Whitten. MitoQ is a world-first, mitochondria-targeted CoQ10 antioxidant. I havent. There might be some sort of infection or overgrowth also in this same umbrella of addressing the cause. Theres a gut-immune axis. Mitochondrial dysfunction happens when the function of mitochondria is reduced. Your mitochondria are known as the powerhouses of a cell for a reason. Theyre not diseases of individual genetics and biochemistry, theyre diseases of nutrition and lifestyle. Now, I mean, that is pretty mind blowing in and of itself because so many people are walking around thinking Ive got these symptoms, Im going to go to my doctor. Sure, thyroid, if youre frankly hypothyroid but outside of that, weve gotta start looking upstream. Look to the Hunter-Gatherers, Gut Check: Debunking the Probiotics Are Harmful Myth, A Simple & Effective Leaky Gut Repair Protocol, Gut Talk: Updates to Gut Research (June 2023), A First Responder Health Program That Addresses Mental AND Physical Wellness. And this really, I think gets at a broader concept that I really harp on a lot and I dont think gets enough attention and appreciation, and that is that every system in the body is connected and nothing occurs in isolation. Hear about the probiotic protocol to follow. Of course, circadian rhythm and sleep have a massive effect on mitochondria, on many different hormones, and on neurotransmitters and many, many different aspects of our physiology. If case you are in need of help, or would like to learn more, I wanted to quickly point out what resources are available to you. And then from there now they have the energy to start to implement some of those foundational nutrition and lifestyle habits. To give you an idea theres research, lets say on Rhodiola rose as an example, looking at multiple actions, theres research on it looking at how it modulates the HPA axis. And what theyve shown is that mitochondrial capacity (basically the number of mitochondria you have in each cell) declines on average by about 10% with each decade of life. You have fatigue as a symptom of that flu that is happening to you in this moment. 11 of the 59 studies found the exact opposite finding, slightly higher morning cortisol levels in the group thats fatigued relative to healthy people. Its not working the brain necessarily in any sort of direct way. The brain and liver are also very energy dependent and have lots of mitochondria. And thats how we end up where we are. Todays topic was a real unpacking of mitochondrial health. Again, its called Eat for Energy: How to Beat Fatigue, Supercharge Your Mitochondria and Unlock All Day Energy. He holds an MS in human nutrition and functional health and a BS in kinesiology with additional certifications in corrective exercise and performance enhancement from the National Academy of Sports medicine and has completed some coursework towards a clinical psychology PhD. Okay. And hes discussed with us in the past many techniques for optimizing mitochondrial function and this should be a nice continuation of that. Herbs Spices Other healthy foods that supply essential nutrients. So thats one way of thinking about it. So just visit drruscio.com/EH. Aging Process and 'Cell Hacking' - Healthline Our energy levels are basically a reflection of the degree to which our mitochondria perceive themselves to be under threat or not under threat. In This Episode There are several easy steps to follow. Because the healthcare provider comes back and thinks the same thing. Were racking em up. Aging. How Do You Improve Mitochondria Health? The problem with focusing on adrenals 17:17 Its specific genetic strains of mice that respond with the longevity benefit. Really appreciate it. That doesnt mean that they are dysfunctional. Its also an incredibly important tool for a specific context of person who is severely chronically fatigued, who is burnt out, who feels like they have tried a whole bunch of stuff, theyve spent thousands of dollars, theyve seen a whole bunch of practitioners, and they still are suffering from those symptoms and they maybe dont have the energy and the drive to go do more intensive lifestyle alterations. Although, spoiler alert, you probably dont want to perform this test. Thats DRRUSCIO.com. How To Care For Your Mitochondria Set the scene: Provide the mitochondria with the correct environment to thrive in. MitochondriaFundamental to Life and Health - PMC Okay. So a test that tests for mitochondrial dysfunction is not necessarily the same as what Im talking about. And maybe from blood sugar and people who are not in great health, they may have blood sugar regulation problems with extended fasting. If we look at exercise, we can show a similar effect, right? That chapter is really worth the price of the book itself. Why? And then on the other side of the screen, Im envisioning this screenshot that one of the doctors in our clinic sent to me in our, our group WhatsApp. How protein can support your mitochondrial health You can support your mitochondria by eating plenty of protein. I didnt know that breath holding was a stimulus, but I guess its probably a similar hormetic stressor of causing hypoxia-like exercises and thats going to create this healthy adaptation. And independent of the clinic, if youre reading the book or need some general advice, we offer health coaching also. At maximal exercise, this number can increase to 0.5 to 1.0 kg per minutea truly remarkable indication of intense metabolic activity. And if the adrenal fatigue hypothesis is true, this is extraordinarily easy to verify from this study. And Ive experimented with a few people. Its meant to be basically heres everything we know about people with chronic fatigue and how to treat them, how to diagnose it, how to figure out whats growing wrong with them, and how to treat them. And so its essentially evidence-based guidelines for physicians, how to treat their patients with chronic fatigue. Health News Why Scientists Think 'Hacking Our Cells' Could Turn Off the Aging Process Cutting carbs, reducing calories, and using key supplements may help your cells produce more energy and. And so if someone says, I felt better from adrenal support, we should be very careful not to conclude erroneously that it was because there was some sort of adrenal dysfunction. So theres all kinds of theories out there as far as what controls human energy levels. For Way, this is a rapidly sliding scale from simpler problems to more serious ones. So, I really always enjoy our time together. I have no problem with fasting and I can. Ari Whittenauthor of Eat for Energy: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energyprovides nutrition and lifestyle strategies that can be a gamechanger for improving your mitochondrial function and enhancing your energy, focus, mood, and memory. And finally, there is our clinicians newsletter, the FFHR, AKA the Future of Functional Health Review database with research reviews, case studies, and other helpful resources for healthcare providers. (3) Amazon and the Amazon logo are trademarks of Amazon.com, Inc, or its affiliates. Gut-butt too right? Now this is a good reminder for me to consider experimenting with this in that cohort of individual. Dr. Joel Kahn provides the answer. One of the things that we dont do much of in the clinic is direct antiviral support. And the way that they do these studies, this is the type of test that Im referring to, they take a big hollow needle and they jab it into your thigh and they pull out a chunk of your quadricep muscle and they look at it under a microscope and literally count the number of mitochondria in your cells. Its actually the result of mitochondrial shutdown of whats called the cell danger response. So lets say that you get a flu tomorrow and youre fatigued. Alpha Lipoic Acid, CoQ10, fish or krill oil, magnesium, B vitamins, L carnitine, PQQ, and glutathione are recommended by Designs for Health Australia. Let me give you some specific numbers and data on this. I would say our testing for fatigue and mitochondrial function is even way more limited in terms of accuracy and clinical validity. 2. Thats exactly right. . In those cases, there are supplements that have been shown to massively improve energy levels in people with stress-related fatigue and exhaustion. Compared to moderate continuous intensity training and high-intensity interval training (HIIT . An enormous amount of research in recent years suggests that mitochondria play a key role in the aging process and most age-related diseases So its a pleasure to have you back because I always enjoy our chats. Managing Your Mitochondria: Exercise | Mark's Daily Apple So Ari is the founder of the Energy Blueprint System, a comprehensive lifestyle and supplement program, which has helped more than 2 million people around the world to have better health, performance, and energy. And it was a screenshot of, Im not going to name the body, but its one of the biggest educational bodies in functional health. It has been shown in several studies that, just taking healthy people, not even people with fatigue, but healthy people who have no symptoms who are either morning people or night-owl chronotypes and you measure their cortisol levels in the morning. The research Ive seen on fasting thus far is not that compelling. Thats DRRUSCIO.com. Thats a fantastic analogy. (ATP) must be produced by the mitochondria every second of every day because ATP cannot be stored. And I just love the entire framework of And sure, Coq10 and the like supplementation, for that. Some experience big longevity benefits. Healthy Gut, Healthy You, my book and your complete self-help guide to healing your gut. And their job is basically to take in carbs and fats and pump out energy in the form of ATP (adenosine triphosphate). Thats another mechanism of how it affects energy and mood. So to the degree that they are picking up on threats or dangers present in the body, they are turning down the dial on energy production and shifting resources towards cellular defense. But before we get there, so as to make sure we dont go to the 201 level discussion, maybe just frame for people from a high level a reminder what the mitochondria are, why theyre important, and then some of the basics in terms of mitochondrial health. None. 7 Science Backed Steps to Optimize Mitochondrial Health Remember that. And we published a case study in our clinicians newsletter about this about a year ago of a gentleman who was feeling pretty well overall, he was just trying to buffer some of the jet lag and circadian disruption from flying and having to do work from the US to Asia and his adrenal test came back in the tank. So thats another concern that I had that leads to a lot of false positives. Like theres no sense in forcing yourself to go experience hellacious sleep. And thats exactly what our body does at the cellular level orchestrated by mitochondria. This has been fantastic. There isn't a cure, but treatment can prevent life-threatening complications. One thing, if youll humor me here, Im trying to get better about doing is reading the guest bio before the actual conversation begins. Theres also research looking at how it modulates mitochondrial functions. And this is where a lot of this comes from is supplement company influence combined with this reductionistic educational appeal where for some reason, some providers still think the doctor up there on stagewho says the most pleonastic argument with all these details, some of what you can understand some of what you cant, but you cant quite understand it so it means theyre really smart and you better pay attention and just do what they saystill resides as a preferential method of education. Theres obviously a value of tests and there are certain tests that have really good, amazing clinical utility and can be extraordinarily helpful in identifying a problem. Well, all right. Thank you so much. Mitochondrial diseases are a group of genetic conditions that affect how mitochondria in your cells produce energy. Hey there. What studies actually show about adrenal function and fatigue 30:40 Then they go implement those changes, they notice those improvements, they are likely to conclude, oh wow, all these things really fixed my adrenal function and now Im feeling better. Except all of those things that I just mentioned act on dozens of other pathways and mechanisms and systems of the body beyond just the adrenals. But the problem with it is that it only identifies something in five out of every 100 cases for people with chronic fatigue. Im talking half. When mitochondria are compromised, there is increased risk for autoimmune diseases like arthritis. I care about answering your questions and sharing my knowledge with you. I mean, you can send the same exact sample but with different names on it and get totally different results back. Right. I think I feel better. That will last for a number of months, but then eventually the placebo effect wears off. Lets say you and I were together in this moment and we were in the Ukraine somewhere. Overall, I would say that my impressions are this: I am open to the possibility that longer term fasting probably does has have some unique benefits in terms of maybe activating stem cells or rejuvenating immune function or gut health or something like that. So my personal journey was that I dealt personally, when I was in my mid twenties, with severe chronic fatigue after a bout of heavy mononucleosis. And all of a sudden the Russians started attacking. We looked into it, but the more we looked into itI mean maybe, but you really have to be making a lot of inferences to use that test in clinical practice. However, in the last 10 years, its also been discovered that mitochondria have a second role that is just as important as their role as energy generators. One study has suggested that boosting the health of your mitochondria can diminish the cell's chances of ageing. And let me add a few nuances to what you just said specific to this topic of mitochondria. Some ways include: Its not their unique biochemistry that all of a sudden decided to cause these epidemics of all these different diseases and chronic fatigue. This means eating tons of processed foods, refined grains, sugar, fats high in Omega-6 content, and other obviously unhealthy foods should worry you: "HFD [high fat diet]- and HFD plus fructose-fed mice have decreased CTP1a activity, the rate-limiting enzyme of fatty acid oxidation, whereas knockdown of . Hi, everyone. They show them equally effective in reducing weight and improving metabolic health. Hes also the best-selling author of the Ultimate Guide to Red Light Therapy, which we discussed on the podcast a few years back. Sometimes youll see improvements with antivirals, but the more I looked at them, a lot of these antivirals are also either immune modulating, meaning theyre antihistamine as one example, or they may be antimicrobial. We looked into it. This includes foods such as Meat Fish Nuts Seeds Beans / Lentils Eggs These foods support amino acids like glutathione which protect the mitochondria. Another analogy that Ill say here is sort of to understand why the body does this. My body definitely likes to have carbs in the diet, but I am actually tolerant of fasting. We have just standard indoor room lighting is suppressing our melatonin levels by upwards of 70% every night. When we had John Kaiser on the podcast, he had mentioned the seahorse test. Work with Dr. Ruscios, DC, Health Coach! 100%. The connections between systems in the body 35:02 Hi everyone. And it actually rarely comes up in interviews so Im relishing this opportunity. Well-established lots of research. So youre suppressing levels of this critically important mitochondrial protective compound that gets into our mitochondria and actually recharges the internal ARE (antioxidant response element). We also know that melatonin is not just a sleep hormone. I know my brother, who like us is, is also very fit and healthy. And maybe I can just play off of what you just said and add a bit to it. And I actually have all of this published, including the screenshots of all of these dozens of studies that examined cortisol levels. In this article we take a closer look at what mitochondria are, what they do and 5 simple steps you can take to protect them. Their job is to power nearly every function and biochemical process that happens in your body. Several amino acids (glycine, cysteine, and glutamic acid) make up glutathione. Theyre deciding whether the bodys going to be in energy mode or defense mode and where on that spectrum the bodys going to operate. Now theres a few things here that Id love to unpack in a little more detail regarding some of the nuance applications for how do we need to optimize mitochondria. Keeping your heart and mitochondria healthy is important. L-Carnitine The very brief summary of a year of my life is this: that research overwhelmingly shows no discernible connection, no correlation whatsoever between cortisol levels, adrenal function, and the symptom of fatigue. Other research suggests that a process called autophagy helps to keep mitochondria These organelles also regulate critical cellular processes, such as calcium homeostasis, and cell survival (Giorgi et al., 2018; Sprenger and Langer, 2019; Fan et al., 2020).Thus, their health is critical to maintaining wellness in organs and tissues (Youle .

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