How are proteomics services performed using mass spectrometry services? Mass Spectrometry Testing - TCA Lab / Alfa Chemistry Let's discuss the custom services with our experts for free. 888.319.5343. High-resolution mass spectrometry is a powerful tool used at KBI Biopharma for analytical strategies concerning complex samples. Add mass spectrometry to your IC analysis to maximize your ability to detect and quantify unexpected co-elutions or confirm trace components. Gas Chromatography Testing and Analysis - Intertek The entire system is controlled by software that enables operating all units together, as well as acquiring and interpreting data for the final output, i.e., report on quantitative analysis of the drug. What if there were no window on this device? Obtain unique insights into the history and origin of your compounds with precision and sensitivity. Contact us today for your Gas Chromatography Mass Spectrometry (GC-MS) needs at +1 800-366-3867 or please complete the form below to have an EAG expert contact you. The number of test runs . With LC, separation of the sample components is based on the interactions of the compounds with the mobile and stationary phases, and the degree of . NorthEast BioLab provides critical insight, and are compliant with regulatory standards and industry best practices. Mass spectrometry analysis coupled with Liquid chromatography can be used for the analysis of drugs from these studies. Simply stated, GC/MS analysis is an analytical technique used to separate, identify, and quantify all the compounds within a sample. The sample then flows into the mass spectrometer where its bombarded with electrons to further breakdown and quantify compounds in a sample. We use a variety of modern instrumentation to address most applications, including liquid (LC/MS) and gas chromatography coupled to mass spectrometers (single and triple quadrupoles, TOF, and high-resolution quadrupole-TOF systems capable of accurate mass and tandem MS), MALDI-MS, and a time-of-flight-secondary ion mass spectrometer (TOF-SIMS) for surface analysis. This study, same as all other bioanalytical studies with NorthEast BioLab, was completed with top quality and reporting standard with incredible responsiveness. Epoxy outgassing using GC/MS was conducted on both a failed and good sample and it was found that the two samples had dramatically different concentrations of Benzene. PPB range sensitivity, PPT sensitivity achievable, Typical amu range 35-550. In these cases, Interteks team of researchers develop new mass spectrometry based methods rapidly using a wide array of applications to address these problems. Essentially 0.18 g sample consumed all of the O2in ampule, When re-analyzed at a lower mass, SO2(Sulfur dioxide) was detected and O2was not completely consumed. For small molecules analysis in biological fluids, Multiple Reaction Monitoring is used to obtain highly selective detection. Bioanalytical Mass Spectrometry Services | Charles River It is a natural complement to standard IVA testing. Secondary Ion Mass Spectrometry - SIMS Testing Services. packaging materials, molded plastic parts, etc. 2023 Charles River Laboratories. Start Testing To improve the accuracy of chemical molecule structure analysis, Gas Chromatography-Mass Spectrometry (GC-MS) combines the functions of Gas Chromatography (GC) and Mass Spectrometry (MS). The Symposium will address the following topics: 1. Identify and characterize organic and inorganic samples at ppm to sub-ppt levels. Our reliable, easy-to-own, efficient process mass spectrometers offer lab-quality gas analysis with multi-port magnetic sector technology. Developing robust chromatography is key to the success of a quantitative mass spectrometry bioanalytical method. The unmatched power of high-resolution mass spectrometry technology allows us to provide customers with incisive qualitive chemical identification and precise quantitative analysis. Extract more sample information and increase confidence in analytical results, even for complex matrices. Our Experienced Scientists Are Ready To Help You, Today! We have worked with NorthEast BioLab for over ten years given their commitment to highest quality bioanalytical data. Bioanalytical Testing & LC/MS/MS Analysis All rights reserved. Services. Field-deployable methods to check food authenticity at the point of . Testing & Analysis / Analytical Laboratories / Mass Spectrometry Analysis Mass Spectrometry Analysis Mass spectroscopy is used to detect and identify unknowns, mixtures, chemical structures, and more. Polymer characterization, such as molecular weight distributions and end group determination, using matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) with complimentary NMR analysis is another area of expertise that gives our customers the assurance and confidence that working with Intertek, a trusted partner, will help them achieve their goals and power ahead safely. Additional risk of HF (Hydrofluoric acid) creation since the product is a fluoropolymer. In addition, the experts in our Mass Spectrometry Testing Laboratory also provide a variety of custom services as your needs and requirements. Or perhaps address a chemical question posed in a regulatory review? Mass Spectrometry Services | Charles River Sometimes the answers to our customers problems cannot be solved by a standard method. Secondary Ion Mass Spectroscopy (SIMS) is a tool for the composition analysis of metals, semiconductors, polymers, biomaterials, minerals, rocks, and ceramics. Explore cell biology with Thermo Scientific mass spectrometers, leaders in proteomic research. Isotopic and elemental analysis for food authenticity and verification of production and geographical origin. These components will definitely create a corrosive environment, with by products that corrode metal surfaces, and even glass (passivation). Liquid chromatography-tandem mass spectrometry (LC-MS/MS), Liquid chromatography-high resolution mass spectrometry (LC-MS, HRMS), Liquid chromatography (HPLC, UHPLC) with UV, fluorescence, ELSD and radiolabelled detection*, Gas chromatography (GC) with MS, MS/MS, FID and EC detection, Inductively coupled plasma (ICP-OES, ICP-MS), Atmospheric pressure chemical ionization (APCI), SCIEX API 6500, 5500, 5000, 4000, and 7500 (x3), HPLC/UHPLC (Thermo Aria, Waters Acquity and Shimadzu Nexera) with UV, fluorescence, ELSD and radiolabelled detection*, Gas chromatography with MS, MS/MS, FID and EC detection, 96-well plate robotic liquid handlers (Tecan, Hamilton Nimbus and MicroStar, Tomtec). Interteks analytical lab in Allentown, Pennsylvania has decades of experience in mass spectrometry that allows us to develop a detailed plan of testing to solve even the most complex issues. GC/MS testing allows for comprehensive testing of a variety of different substances and sample matrices, from individual compounds to complex mixtures and polymers, offering a level of sensitivity, speed and analysis that cannot be beat. This technique is known as chemical derivatization and is used for enhancing the selectivity and sensitivity of the analyte in mass spectrometry analysis. We recently sat down with Michael J. Nold, Ph.D., Senior Director of KBIs Mass Spectrometry Core Facility in Durham, North Carolina, to discuss how advanced Mass Spectrometry plays asignificantanalytical role in the characterization and quantitation of APIs and impurities in complex biotherapeutics. Scientist, LC-MS/MS Bioanalysis Hamden, CT, USA, Associate Scientist, Central Laboratory Services, Sr. We will respond to your request shortly after the 3rd. Mass Spectrometry | Labcorp Using mass spectrometry based approaches can solve some of the most difficult problems and answer tough questions such as, what is present in a sample, how much, and can the structure of the analyte be identified? trace toxins in plastic products), Identify whether residual solvents are present within pharmaceutical products, Identify odors coming from a product or sample (i.e. Services & Specialties. Put differently, Ion source in the mass spectrometer is responsible for applying a charge to the analyte. Developed by: HQZ Experts, 1) fast turn-around time on sample analysis. Our mass spectrometrists can provide supplementary data for deformulations to identify the unknown, which often utilize multiple techniques, such as nuclear magnetic resonance (NMR), vibrational spectroscopy, or titrations. Services from Mass Spec Lab: Chemical Analysis & Trace-Level Testing KBIs state-of-the-art mass spectrometry core facility delivers unparalleled structural characterization services to our clients. Oneidas GC/MS analysis services can be performed via Static Headspace, solvent extraction and direct injection, direct air injection, residual solvent analysis, gas cylinder analysis, IVA of hermetic devices, and outgassing of samples sealed in ampoules. Some manufacturers may consider testing and certification an obstacle to overcome to get to market. Among other services, CROs provide long term, and large scale bio-analytical support, however, their rapid growth in this area seems to come with caveats. Peptide mapping is used to confirm protein primary structure by determining its amino acid sequence and employing endoproteases (enzymes) to generate peptides, followed by analysis by HPLC coupled with mass spectrometry. Fingerprint maps are a powerful visualization tool we offer to track changes or differences in your materials. Structural elucidation of the unknowns (UV, accurate MS, & MSMS fragmentation data) thus becomes a paramount objective. Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), X-Ray Photoelectron Spectroscopy (XPS) Testing, Nuclear Magnetic Resonance Spectroscopy Testing, Transmission Electron Microscopy (TEM) Lab Services, Scanning Tunneling Microscopy (STM) Lab Services, Atomic Force Microscopy (AFM) Lab Services, Auger Electron Spectroscopy (AES) Lab Services, High Pressure High Temperature (HPHT) Corrosion Testing, Differential Scanning Calorimetry (DSC) Testing, High Temperature Mechanical Properties Testing, Stability Testing of Pharmaceutical Products, Particle Size Distribution Analysis and Testing, Scanning Electron Microscopy (SEM) Laboratory, Infrared Spectrum Processing and Interpretation, Fourier Transform Infrared Spectroscopy (FTIR), Gas Chromatography - Mass Spectrometry (GC-MS), Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), Laser Ablation-Inductively Coupled Plasma Mass Spectrometer (LA-ICP-MS) System, Rutherford Backscattering Spectrometry (RBS), Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS), The Theory and Applications of Compression Testing. Methods and systems to support food authenticity and combat food fraud. NorthEast BioLab tremendously supported us in reproducing our critical lab discoveries for drug metabolism. This allows for effective mitigation of safety risks and ensures product quality. The FDA continuously heighten their standards in the area of Leachables and Extractables test data, expecting data from more sensitive instrumental methods such as LC/MS and microscopic FTIR. HF is extremely difficult to detect, but will attack glass, metals, oxides, etc. With over 20 years of experience in mass spectrometry services, we have a proven track record supporting diverse protein characterization programs including large molecule comparability studies. Sign-up for the Quarterly Newsletter from NorthEast BioLab. Intertek scientists provide extensive mass spectrometry testing, analysis and expertise. Liquid Chromatography Mass Spectrometry (LC-MS) SCIEX mass spec and capillary electrophoresis solutions are designed by scientists with your applications in mind. testing methods (DNA probes and HPLC) was determined. Client knew there were potential issues removing flux residue. Most CROs continuously add capabilities to support large and multisite studies, and, in the current outsourcing climate, have attracted substantial venture capital and grown rapidly. Related terminology: Acylcarnitine, dried blood spot . theYear=theYear+1900 We are thrilled to complete our bioanalytical studies with their top quality and incredibly responsive team. This data can provide valuable insights into the chemistry of analytes with concentration data ranging down to the nanomolar (10 6 mol/m 3) range and, increasingly, as low as the attomolar (10 15 mol/m 3) scale. Chemical Analysis & Trace-Level Testing. Mass Spectrometry Through our global network of testing experts and analytical equipment including chromatography (HPLC, GC, GC/MS) and atomic absorption spectroscopy (AAS, GFA, FIAS), Our goal is to provide test services as efficiently as possible to maximize our customers' profits. Mass Spec Lab is a new bioanalytical startup in Irvine, CA, launched by InVision Biomedical Group, which provides CRO preclinical and clinical build services to the ophthalmic biomedical device sector. Once drug candidates with good bioavailability are selected, additional dose range finding (DRF) studies are performed in various animal species to enable IND filing. Blue trace is system background as detected by analyzing a System Blank. Black trace is sample. Package Gas (for microelectronics, packaged materials like battery pouches, implantable medical devices and malodors in consumer product packaging). Introduced contaminants (tubing/fittings), Unknown bubbles/hermetic package expansion, Compare to bulk materials for fingerprint, Variable Pre-bake Temperature (up to 1100C), Tentatively Identified Compounds (TIC) Summary page using NIST11 Mass Spectral Database (>350,000 spectra), Estimated Concentrations, Chemical name and Chemical Abstract Services (CAS) identifications, Chromatograms and overlays of Chromatograms and Control samples highlighting areas of interest. Mass Spec Lab itself is a bio-analytical CRO, but as it grows it has carefully tried to distinguish itself as a Custom rather than Contract Research Organization. It is particularly beneficial for materials . With years of experience and access to the latest equipment, Charles Rivers quantitative mass spectrometry experts deliver rapid, reliable bioanalytical results for your pharmaceutical, biologics, industrial, and agrochemical applications. Explore Our Mass Spectrometry Services Lab CRO! Liquid Chromatography-Mass Spectroscopy (LC-MS) is an analytical technique used for the separation, identification, and quantification of the chemical constituents of a sample. Achieve faster throughput, deeper coverage, higher sensitivity with accurate and precise quantitation. Mass Spectrometry - Translational Research System Real-time PCR Solutions Targeted Sequencing . Accurate Mass UPLC/UV/QTof MS provide the instrumental and software platforms to satisfy these analysis goals. The Ardia Platform is a scalable software solution connecting projects, people, and instruments, helping scientists get closer to the truth. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); 13805 1st Ave N, Ste 100 Plymouth, MN 55441 888-740-5227 [email protected]. The Thermo Scientific Orbitrap Fusion mass spectrometer is a unique hybrid instrument combining quadrupole, Orbitrap, and linear ion trap mass analysis features including: With three fragmentation modes (CID, HCD, ETD) including multi-stage fragmentation, the system provides a highly flexible platform for biological drug product characterization. Advanced analytical capabilities, including mass spectrometry, are critical for the characterization of active pharmaceutical ingredients (APIs) and managing a diverse population of impurities. Intertek scientists provide extensive mass spectrometry testing,analysis and expertise. No thanks, I dont need to improve my drug approval process, High Quality Mass Spectrometry Services At Industry-Leading Turnaround, Rapid Mass Spectrometry Method Development And GLP Validation, FDA Audited Mass Spectrometry Lab For Your PK Sample Analysis And Stability Testing, High-Value, Tailored Mass Spectrometry Testing For Your Therapeutics And Biomarkers. Modification / degradation analysis including glycosylation; N-terminal pyroglutamic acid, pyroglutamine; C-terminal lysine truncation; deamidation; oxidation; etc. Although mass spectrometry data analysis has become routine, laboratory staff continue to face several challenges given the continually evolving nature of the science and application in sophisticated assays. Testing & Analysis / Analytical Laboratories / Allentown Laboratory / Mass Spectrometry Services - Chemicals & Materials (Allentown Lab) Mass Spectrometry Services - Chemicals & Materials (Allentown Lab) Essential analytical approach for structural elucidation and confirmation or quantitation of low level analytes Identify and quantify unknown compounds in complex matrices with our precision LC-MS systems. Perfume Analysis | Outgassing Testing | Soft Drink Testing | Hard Drive Microcontamination Testing | Cooking Oil Analysis. Innovatech Labs specializes in non-routine lab testing. By providing mass determination with low measurement errors (parts per million, ppm), mass spectrometry enables precise determination of molecular composition. Some compounds are too polar and easy to decompose in the heating process, such as organic acids. NorthEast BioLab has outstanding capabilities for mass spectrometry analysis. Furthermore, the magnetic field is used to deflect the ions at varying velocity depending upon the mass of ions. We offer easy, high-throughput, quantitative workflows for proteins, drug metabolites, pesticides and many other applications. The scientists at NorthEast BioLab are technical experts, who produce high-quality data, on-time, and on-budget. Scientist Pharmacokinetics (PK) Studies, Content Manager, Scientific and Regulatory Writing, Sr. Receive the latest news and insights to your inbox. The Way Forward for Clinical Mass Spectrometry in Hospital - AACC Typically, research and development or quality control, assurance, or operations leaders partner with us to identify unknown contaminants, trace elements, or chemical compositions of samples. Fifteen contributors (83%) chose a new therapeutic drug monitoring (TDM) service, or enhancement of an existing TDM service, as a means to expand LC-MS. Hospital laboratories have the advantage of shorter TDM turnaround times, allowing for more rapid dose optimization (9). Intertek is the industry leader with employees in 1,000 locations in over 100 countries. Testing three eugenol anesthetics residues in culture pond water by GC - MS, Analysis of indoxacarb enantionmers in tea by UPLC - MS/MS, Testing 9,10-anthraquinone in instant tea powder by GC - MS, ASTM D7968, ASTM D7730, ASTM D7731, ASTM D8110, ASTM D7742, ASTM E2838, ASTM E2823, ASTM E2330-19, ASTM E2787, ASTM D8026, ISO 10638, ISO 17294, ISO 18856, ISO/TS 16965, ISO 17734, ISO 17734, ISO 21863, ISO 20647, ISO 16000, ISO 17858, ISO 20636. Call to discuss options. GC/MS Analysis Services - GCMS Lab | Innovatech Labs Proteomics Accurate Mass Nominal Mass for Small Molecules Contract analytical laboratories undoubtedly do great work, and are well suited for large scale, long term, and routine quantitative and qualitative studies. Example of why clients would want to test their materialsmanufacturer claims this product is stable to 750C. Definitelya problem. Residual solvents detected, as well as terpenes from the solder flux. NIST Library Search results for peak at ~10.78 minutes indicating Octamethylcyclotetrasiloxane, 89% Match Quality, Materials of Construction (for satellites, spacecraft, etc.). It is one of the most powerful tools for the identification of pure substances, including determination of relative molecular weight, determination of chemical formula and structure identification. Mass Spec Lab formed in 2014 and launched its online presence in late 2015. Our materials analysis services evaluate material quality and provide the necessary insight to improve performance & resolve failure or contamination issues . High-Resolution Mass Spectrometry (HRMS) - Infinita Lab Furthermore, our lab scientists and analysts always remain fully transparent as our strategic partnership with clients is based out foundational values.

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